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Image Search Results
Journal: Nature genetics
Article Title: Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion
doi: 10.1038/ng.2507
Figure Lengend Snippet: Manhattan plot for the fasting proinsulin analysis. Association results of the single-variant analysis (−log10 P values) are plotted against genomic position (NCBI Build 37). Previously identified loci are denoted in blue and loci identified by the current study in red. Fasting proinsulin levels were log-transformed and adjusted for fasting insulin, body mass index, age, and age2.
Article Snippet:
Techniques: Variant Assay, Transformation Assay
Journal: Nature genetics
Article Title: Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion
doi: 10.1038/ng.2507
Figure Lengend Snippet: Novel low frequency variants at fasting proinsulin loci previously identified by genome-wide association studies
Article Snippet:
Techniques: Genome Wide, Variant Assay
Journal: Nature genetics
Article Title: Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion
doi: 10.1038/ng.2507
Figure Lengend Snippet: The MADD gene is located in a region of unusually high linkage disequilibrium on chromosome 11 from 46 to 57 Mb. Regional association results of the single-variant analysis (−log10 P values) are plotted against genomic position (NCBI Build 37) for fasting proinsulin before (a) and after (b) adjustment of the lead SNPs for the common GWAS signals (rs7944584 and rs1051006) and the nonsense variant rs35233100 (MAF 3.7%) at MADD. Fasting proinsulin levels were log-transformed and adjusted for fasting insulin, body mass index, age, and age2. The conditioning SNPs are indicated in blue. For clarity, only a portion of the 11 Mb region and a subset of the genes are shown.
Article Snippet:
Techniques: Variant Assay, Transformation Assay
Journal: Nature genetics
Article Title: Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion
doi: 10.1038/ng.2507
Figure Lengend Snippet: Novel loci for insulin processing and secretion
Article Snippet:
Techniques:
Journal: Nature genetics
Article Title: Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion
doi: 10.1038/ng.2507
Figure Lengend Snippet: Genes associated with fasting proinsulin identified by gene-based tests of aggregated low-frequency nonsynonymous variants with MAF < 3%
Article Snippet:
Techniques: